本研究以三氯氧磷、二甘醇、乙醇为原料,通过对原料配比、反应温度、催化剂等条件进行优化,分步反应合成二甘醇二磷酸四乙酯。实验表明,第一步三氯氧磷与二甘醇最佳摩尔比为2.5∶1,反应温度为15~18℃,反应时间为3h。第二步乙醇与中间体的最佳摩尔比为8∶1,反应温度为50℃,反应时间为3h。制得的产品收率约为86.5%。 In this study, phosphorus oxychloride, diethylene glycol, ethanol as raw materials, through the raw material ratio, reaction temperature, catalyst and other conditions optimization step by step reaction synthesis of diethylene glycol diphosphate tetraethyl ester. Experiments show that the first step phosphorus oxychloride and diethylene glycol molar ratio of 2.5: 1, the reaction temperature is 15 ~ 18 ℃, the reaction time was 3h. The second step the best molar ratio of ethanol and intermediate 8: 1, the reaction temperature was 50 ℃, the reaction time was 3h. The yield of the product obtained was about 86.5%.