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目的:观察不同年龄段单纯性肥胖儿童血浆单不饱和脂肪酸(monounsaturated fatty acid,MUFA)水平的变化,进而探讨MUFA及体重指数(Body mass index,BMI)与硬脂酰辅酶A去饱和酶(Stearoyl-CoA desaturase,SCD)活性(C16∶1n-7/C16∶0及C18∶1n-9/C18∶0)之间的关系。方法:选取北京酒仙桥地区2005年5月～2007年5月在清华大学第一附属医院保健科进行健康体检的儿童共152名,其中0～6月龄和7～12月龄婴儿各40名,1～6岁儿童72名;所有儿童中肥胖儿73名、体重正常儿79名。利用气相色谱分析方法测定其血浆脂肪酸组成。结果:6月龄以下肥胖儿童血浆MUFA水平与正常儿童之间无明显差异;7～12月龄肥胖儿童血浆棕榈油酸(palmitoleate acid,C16∶1n-7)、单不饱和脂肪酸总量(MUFAs)及SCD活性均较正常儿童升高(P<0.05);1岁以后,血浆油酸(oleate acid,C18∶1n-9)亦较正常儿童明显升高(P<0.05)。相关性分析显示,儿童血浆C16∶1与SCD活性呈正相关(P<0.001),肥胖儿童BMI与SCD活性呈正相关(P<0.01)。结论:随着年龄的增长,肥胖儿童血浆MUFA水平紊乱情况逐步加重,这种变化可能是机体为降低血脂水平、以及抵抗其它病理生理反应而进行的适应性调节现象。
OBJECTIVE: To observe the changes of plasma monounsaturated fatty acid (MUFA) levels in simple obese children of different ages and to explore the relationship between MUFA and body mass index (BMI) and Stearoyl -CoA desaturase, SCD) activity (C16: 1 n-7 / C16: 0 and C18: 1 n-9 / C18: 0). METHODS: A total of 152 children were enrolled in the Jiuxianqiao district of Beijing from May 2005 to May 2007 at the Health Department of the First Affiliated Hospital of Tsinghua University, in which 40 children aged 0-6 months and 7-12 months , 72 children aged 1 to 6 years old, 73 children with obesity and 79 children with normal weight. The plasma fatty acid composition was determined by gas chromatography. Results: The plasma levels of MUFA in obese children less than 6 months of age had no significant difference compared with normal children. The levels of palmitoleate acid (C16: 1n-7), monounsaturated fatty acids (MUFAs) in obese children aged 7-12 months ) And SCD activity were significantly higher than those in normal children (P <0.05). After 1 year of age, oleate acid (C18: 1n-9) was significantly higher than that of normal children (P <0.05). Correlation analysis showed that there was a positive correlation between plasma C16:1 and SCD activity in children (P <0.001), and positive correlation between BMI and SCD activity in obese children (P <0.01). CONCLUSION: As the age increases, the level of plasma MUFA in obese children gradually aggravates. This change may be the adaptive regulation of the body to reduce blood lipid levels and resist other pathophysiological responses.