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目的:观察环磷腺苷葡胺(MAC)辅助治疗老年人慢性充血性心力衰竭的疗效及其对胱抑素C(Cys-C)、血浆B型利钠肽(BNP)的影响。方法:选择武警海警总队医院2017年8月至2018年8月收治的老年慢性充血性心力衰竭患者110例为观察对象，采用随机数字表法分为对照组55例、观察组55例。对照组采用常规治疗，观察组在常规治疗基础上联合MAC治疗，两组疗程均为2周。比较两组临床疗效及左室射血分数(LVEF)、心输出量、Cys-C、血浆BNP的变化。结果:观察组总好转率为94.55%(52/55)，高于对照组的78.18%(43/55)，差异有统计学意义(χn 2＝6.253，n P0.05)；治疗后，观察组LVEF[(44.16±6.82)%]、心输出量[(8.07±1.45)L/min]均明显高于对照组[(40.71±5.38)%、(6.44±1.37)L/min]，BNP[(1.65±0.24)mg/L]、Cys-C[(552.79±10.46)mg/L]均明显低于对照组[(2.31±0.48)mg/L、(681.73±12.71)mg/L]，均差异有统计学意义(n t＝2.945、6.060、9.121、0.551，均n P<0.05)。n 结论:MAC辅助治疗老年慢性充血性心力衰竭患者有显著的疗效，可改善患者的心功能，降低血浆Cys-C、BNP浓度。“,”Objective:To observe the efficacy of meglumine adenosine cyclophosphate (MAC) in the adjuvant treatment of chronic congestive heart failure(CHF) in the elderly, and its effects on cystatin C(Cys-C) and plasma B-type natriuretic peptide(BNP).Methods:From August 2017 to August 2018, 110 elderly patients with chronic CHF admitted to Zhejiang Provincial Armed Police Corps Hospital were selected and randomly divided into control group(55 cases) and observation group(55 cases) by random number table method.The control group was treated with routine treatment, while the observation group was treated with MAC on the basis of routine treatment.Both two groups were treated for 2 weeks.The clinical efficacy, left ventricular ejection fraction (LVEF), cardiac output, Cys-C and plasma BNP were compared between the two groups.Results:The total improvement rate of the observation group was 94.55%(52/55), which was higher than 78.18%(43/55) of the control group, the difference was statistically significant(χn 2=6.253, n P0.05). After treatment, the LVEF[(44.16±6.82)%], cardiac output[(8.07±1.45)L/min] of the observation group were significantly higher than those of the control group[(40.71±5.38)%, (6.44±1.37)L/min], and BNP[(1.65±0.24)mg/L], Cys-C[(552.79±10.46)mg/L] of the observation group were significantly lower than those of the control group[(2.31±0.48)mg/L, (681.73±12.71)mg/L], the differences were statistically significant(n t=2.945, 6.060, 9.121, 0.551, all n P<0.05).n Conclusion:MAC has significant effect in the treatment of elderly patients with chronic CHF.It can improve the cardiac function of patients and reduce the plasma concentrations of Cys-C and BNP.