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目的将人胚胎干细胞诱导分化成的肾前体细胞移植入小鼠模型,探讨其对慢性肾衰所致肾功能恢复的能力。方法将人胚胎干细胞诱导分化成的肾前体细胞移植入慢性肾功能衰竭小鼠体内1、7、15 d后,检测小鼠的相关肾功能指标以客观反映肾功能恢复情况。结果将人胚胎干细胞来源的肾前细胞移植入肾衰小鼠模型后,肾功能生化指标与模型组相比,差别有统计学意义(P<0.05),肾功能得到明显改善。结论人胚胎干细胞移植入小鼠体内后参与受体肾组织的再生,对慢性肾衰竭起到明显的抑制及延缓作用。
OBJECTIVE: Transplantation of human embryonic stem cell-derived preneoplastic cells into mouse models to investigate its ability to recover renal function caused by chronic renal failure. Methods The renal precursor cells differentiated from human embryonic stem cells were transplanted into mice with chronic renal failure for 1, 7, 15 days. The indexes of renal function in mice were detected to objectively reflect the recovery of renal function. Results After transplanted human embryonic stem cell-derived prenecytes into renal failure mouse model, the renal biochemical parameters were significantly different from those of the model group (P <0.05), and the renal function was significantly improved. Conclusion Human embryonic stem cells are implanted into the body of mice to participate in the regeneration of the kidney of the recipient, which obviously inhibits and delays the development of chronic renal failure.