细胞色素P450(cytochrome P450,CYP450)是一组结构和功能相关的超家族基因编码的同工酶,主要存在于人的肝脏中,参与许多内源性以及外源性物质的生物转化,外源性物质特别是药物进入体内以后,很多都是经过肝脏代谢,而CYP450是肝代谢药物的主要酶系。CYP450可受遗传、年龄、疾病等多种因素的影响,尤其是药物可显著影响药酶的活性,加速或减缓底物和其他药物代谢。CYP450同工酶 Cytochrome P450 (CYP450) is a group of isoenzymes encoded by a set of structurally and functionally related superfamily genes, mainly found in the human liver, involved in the biotransformation of many endogenous and exogenous substances, exogenous Sexual substances, especially drugs into the body, many of them are through the liver metabolism, and CYP450 is the main enzyme of liver metabolism drugs. CYP450 by genetic factors, age, disease and other factors, especially drugs can significantly affect the enzyme activity, accelerate or slow the metabolism of substrates and other drugs. CYP450 isoenzyme