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目前用于制剂灭菌的传统方法主要有冷、热灭菌法和化学灭菌法。~(60)Co-γ射线灭菌是一种新型物理方法,成本低,不对药物产生化学污染,且能达到上述普通灭菌方法的效果,因而在制剂的灭菌方面具有很大的应用潜力。我们使用~(60)Co-γ射线对制剂灭菌作了研究,并作了对小鼠的急性毒性、薄层色谱对照分析的实验,现将结果报道如下。
At present, the traditional methods for preparation sterilization are mainly cold, heat sterilization and chemical sterilization. ~ (60) Co-γ-ray sterilization is a new type of physical method with low cost, no chemical pollution to the drug, and can achieve the effect of the above general sterilization method, and thus has great potential in the sterilization of the preparation . We used ~ (60) Co-γ-ray irradiation to sterilize the preparation, and made acute toxicity to mice, TLC analysis of the experiment, the results are reported below.