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目的探讨纳洛酮在治疗急性有机磷农药中毒(AOPP)中的作用。方法随机选择两组患者,分为治疗组与对照组,两组患者均给予常规抢救方法:反复洗胃,清洗皮肤减少毒物再吸收,阿托品及解磷定的运用,输液、利尿排毒支持及对症治疗。治疗组在上述治疗的基础上加用纳洛酮,首先给予静推0.8~1.2mg,而后给予维持量0.01mg/m in,观察两组患者阿托品化时间(h)及胆碱酯酶(ChE)活力恢复程度,及两组患者阿托品用药总量、用药次数、治愈时间。结果治疗组阿托品化时间缩短,胆碱酯酶活力恢复程度增高,阿托品用药总量减少,用药次数减少,治愈时间缩短。结论纳洛酮在AOPP抢救中起积极的辅助治疗作用。
Objective To investigate the role of naloxone in the treatment of acute organophosphorus pesticide poisoning (AOPP). Methods Two groups of patients were randomly divided into treatment group and control group. Both groups were given routine salvage methods: repeated gastric lavage, cleansing skin to reduce reabsorption of arsenic, use of atropine and phoxim, infusion and detoxification support and symptomatic treatment. In the treatment group, Naloxone was added on the basis of the above treatment. First, 0.8 to 1.2 mg of the drug was given to the patients in the treatment group, and then the maintenance dose of 0.01 mg / m in was given. The time of administration of atropine (h) and ChE ) Vitality recovery, and the two groups of patients with atropine medication, medication frequency, cure time. Results In the treatment group, the time of atropistillation was shortened and the degree of recovery of cholinesterase activity was increased. The total amount of atropine used was decreased, the number of medication was decreased, and the healing time was shortened. Conclusion Naloxone plays an active adjuvant therapy in the rescue of AOPP.