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目的 :为了探讨宫颈肿瘤患者血清中VEGF ,IL la和IL 6水平。方法 :用化学发光法测定了 35例宫颈癌 ,2 4例宫颈上皮内瘤样变 ,18例腺肌瘤和 2 4例正常对照者血中VEGF ,IL la和IL 6。结果 :宫颈癌患者血清中VEGF明显高于对照组 (P <0 .0 5 ) ,IL 6明显高于对照组 (P <0 .0 1) ,IL la间差异无显著性 (P >0 .0 5 ) ;宫颈上皮内瘤样变患者血清中VEGF明显高于对照组 (P <0 .0 1) ,IL la间差异无显著性 (P <0 .0 5 ) ,宫颈上皮内瘤样变患者血清中VEGF明显高于对照组 (P <0 .0 5 ) ,IL 6明显高于对照组 (P <0 .0 5 ) ,IL la间差异无显著性 (P >0 .0 5 ) ;腺肌瘤患者血清中VEGF明显高于对照组 (P <0 .0 5 ) ,IL 6明显高于对照组 (P <0 .0 5 ) ,IL la间差异无显著性 (P >0 .0 5 ) ,结论 :宫颈癌、宫颈上皮内瘤样变和腺肌瘤患者血清中VEGF和IL 6水平明显升高。
Objective: To investigate the serum levels of VEGF, IL la and IL 6 in cervical cancer patients. Methods: The levels of VEGF, IL la and IL 6 in 35 cases of cervical cancer, 24 cases of cervical intraepithelial neoplasia, 18 cases of adenomyosis and 24 cases of normal controls were determined by chemiluminescence method. Results: The serum VEGF of patients with cervical cancer was significantly higher than that of the control group (P <0.05), IL 6 was significantly higher than that of the control group (P <0.01), IL la was not significantly different (P> 0.05). The serum level of VEGF in patients with cervical intraepithelial neoplasia was significantly higher than that in the control group (P <0.01), but there was no significant difference between IL la (P <0.05), cervical intraepithelial neoplasia Serum levels of VEGF in patients were significantly higher than those in control group (P <0.05), IL 6 was significantly higher than that in control group (P <0.05), IL la was not significantly different (P> 0.05); Serum VEGF of patients with adenomyosis was significantly higher than that of the control group (P <0.05), IL 6 was significantly higher than that of the control group (P <0.05), IL la was no significant difference (P> 0. 0 5). Conclusion: The serum levels of VEGF and IL-6 in patients with cervical cancer, cervical intraepithelial neoplasia and adenomyosis were significantly increased.