电镜检查在肾活检病理诊断中发挥着重要作用,多数肾活检病理诊断病例需要依靠电镜明确诊断或起到重要的辅助诊断作用。对于遗传性肾小球疾病其重要性更为突出,薄基底膜病诊断完全依靠电镜,而Alport综合征、Fabry病、胶原Ⅲ肾小球病等的肾组织超微结构改变均具特异性,因此高度怀疑遗传性肾小球疾病者应保证足够的组织行电镜检查。 Electron microscopy in renal biopsy pathological diagnosis plays an important role in the majority of renal biopsy pathological diagnosis cases need to rely on electron microscopy diagnosis or play an important auxiliary diagnosis. The importance of hereditary glomerular disease is more prominent, thin basement membrane disease diagnosis depends entirely on electron microscopy, and Alport syndrome, Fabry disease, collagen Ⅲ glomerular disease and other renal ultrastructure changes are specific, Therefore, a high degree of suspicion of patients with hereditary glomerular disease should ensure that enough tissue electron microscopy.