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目的探讨血清降钙素原(PCT)在成人肺炎支原体肺炎(MPP)及其合并细菌感染肺炎中的临床价值。方法临床确诊2013年6月~2014年6月广州中医药大学附属茂名市中医院成人肺炎支原体肺炎患者85例,其中合并细菌感染者20例,正常成人体检者40例做对照,采用酶联荧光免疫分析技术测定其血清PCT。结果 65例单纯成人MPP患者血清PCT为(0.04±0.01)μg/L,对照组为(0.03±0.01)μg/L,两者差异无统计学意义(P>0.05),20例合并细菌感染的成人MPP患者血清PCT为(1.20±0.56)μg/L,较单纯成人MPP患者血清PCT明显升高,差异有高度统计学意义(P<0.01)。结论检测血清PCT有助于鉴别成人MPP是否合并细菌感染,并可进行病情监测和疗效的判断。这对临床医生合理使用抗生素具有重要的指导意义,值得临床推广应用。
Objective To investigate the clinical value of serum procalcitonin (PCT) in adult patients with Mycoplasma pneumoniae pneumonia (MPP) and its associated bacterial pneumonia. Methods Clinical diagnosis of 85 cases of adult patients with Mycoplasma pneumoniae pneumonia in Maoming Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine from June 2013 to June 2014, of which 20 cases were complicated with bacterial infection and 40 cases were normal adult controls. Enzyme-linked fluorescence Immunoassay technique was used to determine serum PCT. Results The serum PCT of the 65 adult MPP patients was (0.04 ± 0.01) μg / L and that of the control group was (0.03 ± 0.01) μg / L, with no significant difference between the two groups (P> 0.05) The serum PCT of adult MPP patients was (1.20 ± 0.56) μg / L, which was significantly higher than that of pure adult MPP patients (P <0.01). Conclusions Detection of serum PCT can help identify whether adult MPP is associated with bacterial infection, and can be used to monitor the disease and judge its efficacy. This is an important guideline for clinicians to use antibiotics reasonably and is worthy of clinical promotion and application.