导致缬氨酸取代丙氨酸的亚甲基四氢叶酸还原酶 ( MTHFR)基因中一个常见的热不稳定性遗传变异 ( 677C→ T)作为血管病的风险因子已有报道。这种变异与降低的酶活性相关 ,损害了同型半胱氨酸至蛋氨酸的再甲基化 ,继而产生高同型半胱氨酸血症。据报道 C677T等位基因与 -型糖尿病? A common thermolabile genetic variation (677C → T) in the methylenetetrahydrofolate reductase (MTHFR) gene that leads to valine-substituted alanine has been reported as a risk factor for vascular disease. This variation is associated with decreased enzymatic activity, compromising the remethylation of homocysteine ​​to methionine, which in turn produces hyperhomocysteinemia. It is reported that C677T allele and - type diabetes?