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目的探讨肝小静脉闭塞病(HVOD)的临床特点和诊治经验。方法回顾性分析2003年6月至2004年6月诊治8例HVOD的临床资料特点及经验。结果8例均有肝大和顽固性腹水,全部经肝静脉造影和肝脏组织活检确立诊断。其中急性和亚急性5例,慢性3例。5例行门体分流术,好转3例,无效1例,手术死亡1例;3例采用支持治疗,2例好转,1例死亡。结论肝静脉造影和肝脏组织活检可以确诊HOVD,急性或亚急性病人宜采用非手术治疗,一旦出现食管静脉曲张等门静脉高压症状时,可行门体分流和(或)断流手术。
Objective To investigate the clinical features and diagnosis and treatment of hepatic veno-occlusive disease (HVOD). Methods The clinical data of 8 cases of HVOD diagnosed and treated from June 2003 to June 2004 were retrospectively analyzed. Results All the 8 cases had hepatomegaly and intractable ascites, and all of them were diagnosed by hepatic venography and liver biopsy. One acute and subacute in 5 cases, 3 cases of chronic. 5 cases of portal bypass, improved in 3 cases, 1 case of ineffective, 1 case of surgical death; 3 cases of supportive care, 2 cases improved, 1 case of death. Conclusions Hepatic venography and liver biopsy can diagnose HOVD. Acute or subacute patients should be treated with non-surgical treatment. In the event of esophageal varices and other symptoms of portal hypertension, portal bypass and / or disconnection may be feasible.