目的 :研究四种人工半合成槲皮素水溶性衍生物 ,即乙氧基槲皮素、槲皮素磷酸酯 (B)、槲皮素单硫酸酯和槲皮素二硫酸酯对凝血酶诱导兔血小板聚集的影响。方法 :用比浊法检测血小板聚集。结果 :乙氧基槲皮素对血小板聚集无影响 ;槲皮素磷酸酯 (B)、槲皮素单硫酸酯和槲皮素二硫酸酯对血小板聚集有抑制作用 ,IC5 0 分别为 80μ mol/ L、95μ mol/ L和 1 85μ mol/ L。结论 :槲皮素磷酸酯 (B)、槲皮素单硫酸酯和槲皮素二硫酸酯具有抗血小板活性 Objective: To study four artificial semisynthetic quercetin water-soluble derivatives, namely ethoxy quercetin, quercetin phosphate (B), quercetin monosulfate and quercetin disulfate, for thrombin induction. Rabbit platelet aggregation effects. Method : Detection of platelet aggregation by nephelometry. Results: Ethoxy quercetin had no effect on platelet aggregation; quercetin phosphate (B), quercetin monosulfate and quercetin disulfate inhibited platelet aggregation, IC50 was 80 μmol/ L, 95μmol/L and 185μmol/L. Conclusion : Quercetin phosphate (B), quercetin monosulfate and quercetin disulfate have antiplatelet activity