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目的探讨纳洛酮治疗重度窒息新生儿的疗效。方法将86例重度窒息新生儿随机分成2组,2组均采用综合对症支持治疗,治疗组52例生后1min即予纳洛酮脐静脉注射,并持续静脉滴注6h,2次/d,连用7d,观察和比较两组的Apgar评分及惊厥、呼吸衰竭、重度HIE发生率。结果治疗组Apgar评分明显高于对照组(P<0.05),惊厥、呼吸衰竭、重度HIE发生率明显低于对照组(P<0.05),差异有统计学意义。结论对重度窒息新生儿在对症支持治疗基础上尽早并持续使用纳洛酮,能缩短复苏时间,减少并发症发生率。
Objective To investigate the efficacy of naloxone in neonates with severe asphyxia. Methods Eighty-six neonates with severe asphyxia were randomly divided into two groups. All the patients in the two groups were treated with integrated symptomatic supportive therapy. In the treatment group, 52 cases were given intravenous naloxone intravenously 1 min after birth, After 7 days, the Apgar scores, convulsions, respiratory failure and the incidence of severe HIE in both groups were observed and compared. Results The Apgar score of the treatment group was significantly higher than that of the control group (P <0.05). The incidence of seizures, respiratory failure and severe HIE in the treatment group was significantly lower than that in the control group (P <0.05). The difference was statistically significant. Conclusion As early as possible and continuous use of naloxone in symptomatic supportive care for neonates with severe asphyxia can shorten the recovery time and reduce the incidence of complications.