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目的:观察柴枳朴槟汤原方及拆方对小鼠小肠推进和及4 h内排便次数的影响。方法:小鼠随机分成对照组、理气A组、理气B组、活血A组、活血B组、理气活血A组、理气活血B组(原方)、甘草组8组,ig给药10 d后进行小肠推进和排便次数的观察。结果:理气A组、理气B组、理气活血A组和理气活血B组(柴枳朴槟汤原方组)小肠推进率增加,与对照组比较有显著性差异(P<0.05);理气活血A组和理气活血B组(柴枳朴槟汤原方组)湿粪数明显增高,与对照组比较,差异有统计学意义(P<0.05)。结论:原方促胃肠推进优于拆方,理气药、理气药配活血药及理气药、活血药、甘草三者配伍后都可促进小鼠肠蠕动,理气药可能为促进肠推进的主要药物。
OBJECTIVE: To observe the effect of Chai Zhi Bai Ben Tang Decoction and its separate prescriptions on small intestine propulsion and number of defecation in 4 h mice. Methods: The mice were randomly divided into control group, Qi A group, Qi B group, Huoxue A group, Huoxue B group, Qi and Huoxue group A, Qi and Huoxue group B (original), licorice group 8, To observe the number of intestinal propulsion and defecation. Results: The rate of small intestine propulsion was increased in model group A, Qi-Li-B group, Qi-regulating and blood-activating group A and Qi-qi-activating blood group B (Chaiweipibupenggu decoction group), compared with the control group And qi and activating blood circulation group B (Chai Zhi Pu Jing Tang Yuan Fang group) significantly increased the number of wet excrement, compared with the control group, the difference was statistically significant (P <0.05). CONCLUSION: The original side of promoting gastrointestinal prophylaxis is superior to the demolition side, qi medicine, qi medicine with blood circulation and qi medicine, blood circulation drugs, licorice three compatibility can promote mouse peristalsis, qi medicine may promote the main intestinal propulsion drug.