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目的:探讨临床对多囊卵巢综合征不孕症患者实施氯米芬配合二甲双胍治疗的可行性。方法:选取2012年5月至2014年5月来我院治疗的多囊卵巢综合征不孕症患者共64例,同时随机等分成两组,对照组给予单纯氯米芬用药,观察组增服二甲双胍治疗,研究两组的治疗效果。结果:治疗后,观察组的临床总疗效、排卵率分别是90.63%和78.13%,与对照组的62.50%和46.88%相比更高,有统计学意义(P<0.05)。治疗前,两组的FSH、LH等指标水平相仿(P>0.05),经治疗后均出现改善,且观察组相比对照组改善更显著(P<0.05)。治疗期间,两组均有不适症状出现,但对比无统计学意义(P>0.05)。结论:对多囊卵巢综合征不孕症患者实施氯米芬配合二甲双胍进行治疗,疗效更显著,可有效促排卵、调节患者激素水平,且安全性佳,值得临床普及应用。
Objective: To investigate the clinical application of clomiphene in combination with metformin in patients with polycystic ovary syndrome infertility. Methods: A total of 64 patients with polycystic ovary syndrome infertility who were treated in our hospital from May 2012 to May 2014 were randomly divided into two groups. The control group was given clomiphene alone, Metformin treatment, study the treatment effect of two groups. Results: After treatment, the total clinical curative effect and ovulation rate in the observation group were 90.63% and 78.13%, respectively, which were significantly higher than 62.50% and 46.88% in the control group (P <0.05). Before treatment, the levels of FSH and LH in both groups were similar (P> 0.05), and both groups improved after treatment, and the observation group improved more significantly than the control group (P <0.05). During the treatment, both groups had discomfort symptoms, but the comparison was not statistically significant (P> 0.05). Conclusion: The treatment of clomiphene citrate and metformin in infertility patients with polycystic ovary syndrome is more effective, which can effectively promote ovulation and regulate hormone levels in patients with good safety and is worthy of clinical application.