创面愈合是由多种细胞及细胞因子参与的复杂过程,难愈或不愈创面是整形外科的一大挑战。随着人们对脂肪干细胞基础研究及临床应用研究的深入,利用脂肪干细胞来提高创面愈合已被证明是一种非常有前景的治疗策略。在此就脂肪干细胞促进创面愈合的机制、治疗策略的改进、细胞移植途径及临床应用研究等方面的进展进行综述。 Wound healing is a complicated process involving many kinds of cells and cytokines. The difficult or unhealed wounds are a major challenge in plastic surgery. With the further research on basic and clinical application of ADSCs, the use of ADSCs to improve wound healing has proved to be a very promising therapeutic strategy. In this article, we reviewed the progress of the mechanism of promoting the wound healing of adipose-derived stem cells, the improvement of the treatment strategy, the cell transplantation approach and the clinical application.