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目的探讨广西地区先天性甲状腺功能异常(包括先天性甲状腺功能减低症(CH)和高TSH血症)发病率与胎龄、出生体重的关系。方法对2009年9月～2010年12月广西新生儿疾病筛查中心筛查的新生儿,凡滤纸血促甲状腺素(TSH)>8.0mIU/L者予以召回,进行甲状腺功能检查。结果 2009年9月～2010年12月共筛查220 844人,确诊先天性甲状腺功能异常200人,发病率为1/1104。其中,早产儿(胎龄<37周)发病率为1/449,足月儿(37≤胎龄≤42周)发病率为1/1189,过期产儿(胎龄>42周)发病率为1/206,过期产儿发病率高于早产儿及足月产儿(P<0.05)。低出生体重儿﹙<2500g)发病率为1/407,正常体重儿(2500～4000g)发病率为1/1236,巨大儿(>4000g)发病率为1/376,低出生体重儿及巨大儿的先天性甲状腺功能异常发病率明显高于正常体重儿(P<0.01)。结论先天性甲状腺功能异常的发病率与胎龄、出生体重密切相关,过期产儿、巨大儿、低出生体重儿的发病率较高。注意孕期保健防止过期产儿、巨大儿、低出生体重儿,对降低先天性甲状腺功能异常的发生有重大意义。
Objective To investigate the relationship between the incidence of congenital hypothyroidism (including congenital hypothyroidism (CH) and hyper-TSH hyperlipidemia) and gestational age and birth weight in Guangxi. Methods From September 2009 to December 2010, neonates screened by Guangxi Neonatal Disease Screening Center were recalled for thyroid function test. All patients with TSH> 8.0mIU / L were recalled. Results A total of 220 844 people were screened from September 2009 to December 2010. 200 cases of congenital thyroid dysfunction were diagnosed, the incidence rate was 1/1104. Among them, the incidence of preterm children (gestational age <37 weeks) incidence of 1/449, full-term children (37 ≤ gestational age ≤ 42 weeks) incidence of 1/1189, the incidence of obese children (gestational age> 42 weeks) incidence of 1 / 206, the incidence of obese children than premature children and full-term children (P <0.05). The incidence of low birth weight infants (<2500g) is 1/407, that of normal infants (2500-4000g) is 1/1236, that of large infants (> 4000g) is 1/376, that of low birth weight infants and large infants The incidence of congenital thyroid dysfunction was significantly higher than that of normal weight children (P <0.01). Conclusions The incidence of congenital thyroid dysfunction is closely related to gestational age and birth weight. The incidence of obese children, giant children and low birth weight children is high. Pay attention to prevent pregnancy during pregnancy expired children, huge children, low birth weight infants, to reduce the occurrence of congenital thyroid dysfunction is of great significance.