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目的探讨硫酸镁治疗新生儿肺动脉高压的可行性,降低疾病死亡率。方法回顾性分析2014年12月至2016年2月湛江市坡头区人民医院收治的出现肺动脉高压症状的新生儿资料120例,按随机数字表法分为研究组和对照组,每组60例。对照组患儿在常规治疗基础上给予硝普钠治疗,研究组患儿在此基础上加用硫酸镁,观察两组患儿生存率,比较治疗前后两组患儿血气指标水平变化。结果研究组患儿症状改善率为96.7%,对照组为85.0%,研究组较对照组患儿症状改善效果好,差异有统计学意义(P<0.05);治疗前两组患儿动脉血二氧化碳分压(Pa CO2)、动脉血氧分压(Pa O2)、动脉血氧饱和度(Sa O2)水平比较,差异无统计学意义(P>0.05);研究组患儿治疗18 h后血气恢复情况较对照组好,且研究组患儿治疗后Pa CO2、Sa O2水平较对照组改善效果好,差异有统计学意义(P<0.05),但两组Pa O2指标比较,差异无统计学意义(P>0.05)。结论为及时有效地纠正肺动脉高压新生儿的低氧血症,提高患儿的生存率,临床采用硫酸镁治疗,患儿恢复好,血气改善效果好。
Objective To investigate the feasibility of magnesium sulfate in neonatal pulmonary hypertension and reduce the mortality rate. Methods A retrospective analysis of 120 cases of newborns with symptoms of pulmonary hypertension admitted from September 2014 to February 2016 in Pontou District People’s Hospital of Zhanjiang City was divided into study group and control group according to random number table method, . Patients in the control group were treated with sodium nitroprusside on the basis of routine treatment. The children in the study group were given magnesium sulfate on the basis of the above results. The survival rate of the two groups was observed. The changes of blood gas levels were compared between the two groups before and after treatment. Results The symptom improvement rate was 96.7% in the study group and 85.0% in the control group, and the improvement effect was better in the study group than in the control group (P <0.05). Before treatment, the arterial carbon dioxide There was no significant difference in Pa CO2, Pa O2 and Sa O2 between the two groups (P> 0.05). After 18 hours of treatment, the blood gas recovery The situation is better than the control group, and the PaCO 2 and Sa 2 O levels in the study group after treatment are better than the control group, the difference was statistically significant (P <0.05), but the difference was not statistically significant (P> 0.05). Conclusions In order to correct the hypoxemia of neonatal pulmonary hypertension in time and improve the survival rate of children, the clinical use of magnesium sulfate, the recovery of children with good blood gas to improve the effect.