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早在本世纪初人们就已知道精子细胞具有免疫原性并能诱发特异性自身或同种免疫反应[1]。1954年Rumke等[2]首次报道自身免疫可能是男性不育的原因之一。此后人们对精子自身免疫反应进行了大量研究,但是直到目前对人类抗精子自身免疫的许多研究仍限于检测抗精子抗体。而对这些抗体产生的机制及细胞免疫所起的作用了解甚少。众所周知,T、B淋巴细胞系免疫活性细胞,二者以具有辅助/诱导(TH/I)和抑制/细胞毒(Ts/c)功能的淋巴细胞亚群来调节体液和细胞免疫反应的类型和强度[3],所以确定男性生殖道组织内淋巴细胞亚群的准确部位对了解自身免疫性不育症具有重要意义。近年
As early as the beginning of this century, people have known that sperm cells are immunogenic and can induce specific self or alloimmune reactions [1]. In 1954 Rumke et al [2] first reported that autoimmunity may be one of the reasons for male infertility. Since then, many studies have been conducted on the autoimmune response of sperm. However, until now, many studies on the autoimmunity of human antisperm have been limited to the detection of anti-sperm antibodies. Little is known about the mechanisms by which these antibodies develop and the role of cellular immunity. It is well-known that T, B lymphocyte lineage immunocompetent cells, both of which regulate the type of humoral and cellular immune responses, and lymphocyte subsets with helper / induce (TH / I) and inhibitory / cytotoxic (Ts / c) functions and Intensity [3], so to determine the exact location of male genital tract lymphocyte subsets of the understanding of autoimmune infertility is of great significance. in recent years