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儿茶酚胺氧位甲基转移酶(catechol-O-methyltransferase,COMT,EC.2.1.1.6)是一种在人体内广泛存在的酶,它催化儿茶酚胺第3位羟基甲基化,降解儿茶酚胺,是具有生物活性或毒性的儿茶酚胺的主要代谢酶。最近的研究发现COMT的基因第4号外显子存在一个G→A的点突变,使其编码的108位氨
Catechol-O-methyltransferase (COMT, EC.2.1.1.6) is a widespread enzyme in the human body that catalyzes the hydroxymethylation of catecholamines at position 3 to degrade catecholamines, Active or toxic catecholamines are the major metabolic enzymes. A recent study found that COMT gene exon 4 has a G → A point mutation, making it encoded 108 ammonia