肿瘤可以发生许多基因的异常甲基化,尤其是抑癌基因启动子区的高甲基化对肿瘤发生有很重要的作用。DNA甲基化具有可逆性,应用去甲基化药物可以使甲基化逆转。现就DNA甲基化异常与肿瘤发生之间关系的研究进展予以综述,尤其是抗肿瘤治疗方面的突破,总结了去甲基化治疗肿瘤的优缺点,并对今后的研究方向进行展望。 Tumors can occur in many genes abnormal methylation, in particular, tumor suppressor gene promoter hypermethylation of the tumor has a very important role. DNA methylation is reversible, the use of demethylation drugs can reverse the methylation. Now the research progress on the relationship between DNA methylation abnormality and tumorigenesis is summarized, especially the breakthrough in antitumor therapy, the advantages and disadvantages of demethylation therapy are summarized, and the future research directions are prospected.