Kallmann综合征(KS)亦称为性幼稚嗅觉丧失综合征,是儿童性腺发育障碍中较为常见的疾病之一,其发病是由于遗传性单纯性促性腺激素释放激素(GnRH)缺乏。1944年由Kallmann首次报道而命名,临床主要特征为青春期性发育障碍伴(或不伴)嗅觉功能障碍。近年来,随着分子生物学技术的不断 Kallmann’s syndrome (KS), also known as sexual immature olfactory loss syndrome, is one of the more common childhood disorders of gonadal development due to a deficiency of hereditary simple gonadotropin-releasing hormone (GnRH). Named for the first time in 1944 by Kallmann, the main clinical feature is adolescent sexual dysfunction with or without olfactory dysfunction. In recent years, with the continuous development of molecular biology technology