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目的:探讨斑蝥酸钠维生素B6注射液辅助治疗晚期宫颈癌中的疗效。方法:60例晚期宫颈癌患者随机分为观察组和对照组,对照组采用常规放化疗,化疗方案为DP方案,观察组在对照组基础上加用斑蝥酸钠维生素B6注射液。6周后比较两组近期疗效、骨髓抑制不良反应、免疫功能和生活质量。结果:观察组近期疗效总有效率66.7%,显著高于对照组(40.00%,P<0.05);骨髓抑制不良反应程度显著低于对照组(P<0.05)。治疗后两组CD8+、NK细胞、CD8+/CD4+均较治疗前显著改善(P<0.05),且观察组改善优于对照组(P<0.05)。观察组生活质量改善率明显高于对照组(P<0.05)。结论:斑蝥酸钠维生素B6注射液辅助治疗可显著提高晚期宫颈癌患者的近期疗效和免疫功能,减少骨髓抑制,改善患者的生活质量。
Objective: To investigate the efficacy of sodium cantharidate vitamin B6 injection in the treatment of advanced cervical cancer. Methods: Sixty patients with advanced cervical cancer were randomly divided into observation group and control group. The control group was treated with conventional radiotherapy and chemotherapy. The chemotherapy regimen was DP. The observation group was given sodium cantharidin vitamin B6 injection on the basis of the control group. After 6 weeks, the two groups were compared the short-term curative effect, bone marrow suppression adverse reaction, immune function and quality of life. Results: The total effective rate in the observation group was 66.7%, significantly higher than that in the control group (40.00%, P <0.05). The degree of bone marrow suppression adverse reaction was significantly lower than that in the control group (P <0.05). After treatment, the levels of CD8 +, NK cells and CD8 + / CD4 in both groups were significantly improved (P <0.05), and the improvement in the observation group was better than that in the control group (P <0.05). The improvement rate of quality of life in the observation group was significantly higher than that in the control group (P <0.05). Conclusion: The cantharidin sodium vitamin B6 injection adjuvant therapy can significantly improve the late cervical cancer patients with short-term efficacy and immune function, reduce bone marrow suppression and improve patient quality of life.