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通过2-呋喃甲醛与苯甲酰肼缩合得到酰腙配体2-呋喃甲醛缩苯甲酰腙(L)。将L与NiCl2·6H2O、CrCl3·9H2O分别在乙醇与丙酮的混合溶剂中反应,采用溶剂挥发法获得2个不同构型的新型配合物NiL2和CrL3的单晶。采用元素分析、红外光谱、X-射线单晶衍射等手段对配合物NiL2和CrL3进行结构表征,配合物NiL2和CrL3均属于单斜晶系,空间群都为C2/c。NiL2属于平面四方构型,CrL3属于四角双锥构型。热重测试表明配合物NiL2和CrL3均有很好的热稳定性。采用琼脂扩散法测定了配体和配合物对大肠杆菌、金黄色葡萄球菌和绿脓杆菌的抑制活性,结果显示配合物NiL2对金色葡萄球菌有显著的抑制活性。
Condensation of 2-furaldehyde with benzoyl hydrazide gave the acylhydrazone ligand 2-furfurylaldehyde benzoylhydrazone (L). L and NiCl2 · 6H2O and CrCl3 · 9H2O were respectively reacted in a mixed solvent of ethanol and acetone. Two new single crystals of NiL2 and CrL3 with different configurations were obtained by solvent evaporation. The structures of NiL2 and CrL3 were characterized by means of elemental analysis, IR and single crystal X-ray diffraction. The complexes NiL2 and CrL3 belong to the monoclinic system with space group C2 / c. NiL2 belongs to a planar tetragonal configuration, CrL3 belongs to the quadrangular bipyramid configuration. Thermogravimetric tests showed that the complexes NiL2 and CrL3 have good thermal stability. Agar diffusion method was used to determine the inhibitory activity of the ligand and the complex on Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, and the results showed that the complex NiL2 had significant inhibitory activity against Staphylococcus aureus.