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目的探讨东北地区遗传性非息肉病性结直肠癌(HNPCC)家系肠外肿瘤谱的特点。方法对登记的85个严格符合Amsterdam标准Ⅱ的HNPCC家系肠外肿瘤谱特点进行回顾性分析。结果 85个家系中,肿瘤患者509例,原发癌灶589例次,其中结肠癌219例,直肠癌91例,肠外肿瘤279例,肠外肿瘤最常见为肺癌。结论肠外肿瘤是HNPCC家系肿瘤谱的重要组成部分,东北地区常见的肠外肿瘤依次为肺癌、胃癌、子宫内膜癌、肝癌和食管癌。
Objective To investigate the characteristics of parenteral tumor spectrum in hereditary nonpolyposis colorectal cancer (HNPCC) in Northeast China. Methods A retrospective analysis of 85 registered HNPCC family parenteral tumor features in strict accordance with Amsterdam standard Ⅱ was performed. Results Among 85 pedigrees, there were 509 cases of cancer patients and 589 cases of primary cancer cases, including 219 cases of colon cancer, 91 cases of rectal cancer and 279 cases of extraintestinal tumor. The extraintestinal tumor was the most common lung cancer. Conclusion Extra parenchymal tumor is an important part of HNPCC pedigree. The common parenchymal tumors in Northeast China are lung cancer, gastric cancer, endometrial cancer, liver cancer and esophageal cancer.