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目的:观察中药方剂敛肾枫心汤治疗运动神经元病患者流涎过多和夜尿次数增多的疗效。方法:招募2014年6月—2016年11月在上海中医药大学附属曙光医院神经内科门诊就诊或接受住院治疗的符合病例选择标准的52例运动神经元病患者,随机分入敛肾枫心汤治疗组(26例,在西医常规治疗的基础上接受敛肾枫心汤口服治疗)和西医常规治疗组(26例),共治疗6周。测量治疗前后夜间活动量、一昼夜(24 h)流涎总量、夜尿次数和肌萎缩侧索硬化功能量表评分。结果:治疗前2组患者的夜间活动量、一昼夜(24 h)流涎总量、夜尿次数和肌萎缩侧索硬化功能量表评分的差异均无统计学意义(P值均>0.05)。治疗期间,敛肾枫心汤治疗组和西医常规治疗组分别有4例和5例患者脱落或失访。敛肾枫心汤治疗组患者治疗后的夜间活动量、一昼夜(24 h)流涎总量和夜尿次数均较治疗前显著减少(P值均<0.05)。西医常规治疗组治疗前后的夜间活动量、一昼夜(24 h)流涎总量和夜尿次数均无显著变化(P值均>0.05)。2组患者治疗前后肌萎缩侧索硬化功能量表评分均无显著变化(P值均>0.05)。2组患者均未见明显的肝肾功能损害等不良反应。结论:具有补肾敛涩功能的中药方剂敛肾枫心汤能够明显改善运动神经元病患者的流涎过多和夜尿次数增多症状。
Objective: To observe the curative effect of traditional Chinese medicine prescription of convergence Ren Shen Maple Leaf Decoction on hyperextension and nocturnal urination in patients with motor neuron disease. Methods: From June 2014 to November 2016, 52 patients with motor neuron disease who met the criteria of case selection in neurology clinic of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine and were admitted to hospital were randomly divided into three groups: The treatment group (26 cases, receiving traditional Chinese medicine on the basis of routine treatment based on the traditional Chinese medicine Fengleitang oral treatment) and the Western routine treatment group (26 cases) were treated for 6 weeks. The activities of nocturnal activities before and after treatment, the total salivary volume of one day and one night (24 h), the number of nocturia and amyotrophic lateral sclerosis scores were measured. Results: There was no significant difference in nocturnal activity, total diurnal (24 h) salivary glands, nocturnal urinary frequency and amyotrophic lateral sclerosis scores before treatment (P> 0.05). During the treatment period, 4 cases and 5 cases of patients with converging kidney maple heart soup and western medicine group were lost or lost. After treatment, the activity of nocturnal activities in the patients treated with convergence Renfeng Maple Decoction group were significantly lower than those before treatment (all P <0.05). Western routine treatment group before and after treatment of night activity, a day and night (24 h) the total number of drooling and nocturnal frequency had no significant changes (P values> 0.05). There was no significant change in the amyotrophic lateral sclerosis functional scale before and after treatment in both groups (P> 0.05). No obvious adverse effects of liver and kidney dysfunction were found in the two groups. CONCLUSION: The traditional Chinese medicine recipe with the function of reinforcing the kidney and astringent can significantly improve the symptoms of excessive salivation and nocturnal urination in motor neuron disease patients.